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Research Studies, Projects, and Publications

blue circle with orange presentation board and pie chartCollege Health Surveillance Network

College Health Surveillance Network (CHSN) is a multi-institutional, de-identified medical records dataset from student health centers (SHCs) that are part of a nationally representative sample of colleges and universities. CHSN allows for both the collection of medical diagnoses, services, and treatments of university students and the use of this information in epidemiologic and service utilization studies. Founded in 2011 with initial funding support from the CDC, CHSN is the first national effort to use data from electronic medical records of students seeking care at university student health centers to evaluate and monitor the health of the college student population in the United States. For more information on this comprehensive resource, click here.

Student Health Research Database

The Student Health Research Database (SHRD) is a comprehensive integrated data repository which is created through linking multiple routinely collected student datasets across the university campus. The database has over 120,000 student cases from 2009 to the present. This database enables the de-identified following of students from time of first enrollment until graduation. It can serve as a cost-efficient longitudinal data source for multi-departmental surveillance, epidemiologic research, training, and service/quality improvement.

Current Clinical Trials and Studies

  • COVPN 3006: UVA Student COVID-19 Vaccine Study
  • A Rapid Test for COVID-19. IRB-HSR 200236 (in collaboration with UVA School of Arts and Sciences: Department of Chemistry). PI: James Landers, PhD
  • Student Health Research Database IRB-HSR #17141. PI: Christopher Holstege, MD
  • College Health Surveillance Network IRB-HSR #18454. PI: Christopher Holstege, MD
  • Magnesium and Ribloflavin Treatment for Post-Concussion Headache. IRB-HSR #21920. PI: Stephanie Hartman MD
  • Utilization of a screening and referral algorithm versus usual care in clinical decision making involving college students presenting with symptoms commonly associated with eating disorders. IRB-HSR #21292. PI: Tracy Buni, MD

Past Clinical Trials

  • Trends in STI Testing at a Student Health Center at a Public University. IRB-HSR #21736. PI: Karen Ahern, BSN, MBA, 2020.
  • A Phase 2b Randomized Blinded Study to Evaluate SYN023 Compared to Human Rabies Immune Globulin in Post Exposure Prophylaxis of Rabies in Adults with Different Rabies Exposure Risks. IRB-HSR 190039 (in collaboration with the Emergency Medicine Research Office) PI: Christopher Holstege, MD, 2020.
  • Clinical Performance of the Diassess Influenza A and B Test. IRB-HSR #19476 (in collaboration with the Emergency Medicine Research Office). PI:  Mark Sochar, MD
  • A Placebo-Controlled, Dose-Ranging Study of Quadrivalent HPV Virus-like Particle (VLP) Vaccine in 16-23 year old Women. Sponsor: Merck & Co., Inc. 2001-2004. IRB-HSR # 8945. FDA approved for administration as Gardasil Vaccine. PI: Christine Peterson, MD
  • Head Injuries in the College Population. IRB-HSR #2069. PI:  Jessica Simmons, MD
  • Physiological and Psychological Changes Following Sport Concussion. IRB-HSR #17960 (in collaboration with Samuel R. Walton Curry School of Education). PI: Jacob Resch, PhD

Current Projects

  • Project 1: Alcohol intoxication among students presenting to the University hospital emergency department (ED)
  • Project 2: Developing a risk screening algorithm for alcohol and other substance abuse among UVA students – a data linkage study
  • Project 3: Determinants, patterns, and costs of service utilization at the UVA Student Health Center
  • Project 4: MHealth intervention to prevent alcohol and substance abuse for high risk students attending the University Student Health Center clinic

Publications

  • Tanabe K, Hayden M, Zunder B, Holstege CP*.  Identifying Vulnerable Populations at a University during the COVID-19 Pandemic. J Am Coll Health, 2021.
  • Holstege CP, Ngo DA, Borek H, Ait-Daoud N, Davis S, Rege S. Trends and Risk Markers of Student Hazardous Drinking – A Comparative Analysis Using Longitudinally Linked Datasets in a Public University. J Am Coll Health, 2020; October: 1-8. Read Article
  • Kim J, Ngo DA, Rege S, Tolley W, Holstege CP. Impact of Instituting Hard-Waiver on a Student Health Insurance Program at a Public University. J Am Coll Health, 2019. Read Article
  • Ngo DA, Rege SV, Ait-Daoud N, Holstege CP.  Development and validation of a risk predictive model for student alcohol intoxication associated with emergency department visits – a longitudinal data-linkage study. Drug Alcohol Dependence, 2019; 197:102-7. Read Article
  • Nobles AL, Curtis BA, Ngo DA, Vardell E, Holstege CP.  Health insurance literacy: A mixed methods study of college students. J Am Coll Health, 2018; Jul 6:1-37. Read Article
  • Ngo DA, Ait-Daoud N, Rege SV, Holstege C. (2018). Validity of diagnostic coding of alcohol intoxication associated with student university hospital emergency department visits. Addiction Medicine. J Addict Med, 2018; Jun 28. Read Article
  • Ngo DA, Rege SV, Ait-Daoud N, Holstege CP.  Trends in incidence and risk markers of student emergency department visits with alcohol intoxication in a U.S. public university-A longitudinal data linkage study.  Drug Alcohol Depend. 2018 Jul 1;188:341-347. Read Article
  • Ngo DA, Ait-Daoud N, Rege SV, Ding C, Gallion L, Davis S. et al. (2018).  Differentials and trends in emergency department visits due to alcohol intoxication and co-occurring conditions among students in a U.S. public university.  Drug and Alcohol Dependence. 183: 89-95. Read Article
  • Vakkalanka JP, King JD, Holstege CP. Abuse, misuse, and suicidal substance use by children on school property. Clin Toxicol (Phila). 2015; 53(9):901-7. Read Article

National/International Meeting Presentations

  • Tanabe K, Hayden M, Rege S, Holstege CP. The Impact of COVID-19 on Student Health Centers. Presented at the North American Primary Care Research Group (NAPCRG) Annual Meeting (virtual). November, 2020.  
  • Rege S, Tanabe K, Borek H, Holstege C. Trends and Risk Markers of Student Hazardous Drinking – A Comparative Analysis Using Longitudinally Linked Datasets in a U.S. Public University. Presented at the 2020 North American College of Clinical Toxicology (virtual). Published in Clinical Toxicology 2020; 58(10):7.   
  • Ahern KA, Downs A. Reducing Barriers to Improve Access to STI Testing Amond Students at a Major Public University.  Poster Presentation (virtual) at ACHA Annual Meeting.  May 2020. Poster
  • Hendrix K. Comprehensive Trauma Informed Care of the Student Following an Acute Sexual Assault.  Poster Presentation (virtual) at ACHA Annual Meeting. May 2020.
  • Rege SV, Holstege CP. Trends in Student Emergency Department Visits with Mental Health Illness In A U.S. Public University – A Data Linkage Study. Presented at the European Society for Emergency Medicine Congress. Prague, Czech Republic. October 2019.
  • Holstege CP, Ngo DA, Rege S A model of big data linkage to monitor student emergency department visits with intoxication and associated risk markers in a US public university.  Clinical Toxicology, 2019; 57(6): 115.  Presented at the 39th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) in Naples, Italy. May 21-24 2019. Presentation
  • Holstege CP, Ngo DA, Rege S.  Demographic trends in injury with alcohol intoxication associated with emergency department visits among students in a US public university.  Clinical Toxicology, 2019; 57(6): 75.  Presented at the 39th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) in Naples, Italy. May 21-24 2019. Poster
  • Hayden ME, Hartman S. Herpes Zoster in the College Student. Poster presentation at ACHA Conference. May 2019.
  • Borek H, Rege S, Ngo DA, Ait-Daoud N, Mann T, Eisenstat M, Holstege CP.  Novel program development and cross-disciplinary collaboration including the poison center in targeting collegiate alcohol misuse. Clinical Toxicology, 2018; 56(10): 1037. Presented at the 2018 North American Congress of Clinical Toxicology.  Chicago, IL. October, 2018. Poster
  • Ngo DA, Rege S, Ait-Daoud N, Holstege CP.  Development and validation of a risk predictive model for student alcohol intoxication associated with emergency department visits – a longitudinal data linkage study. Clinical Toxicology, 2018; 56(10): 1047. Presented at the 2018 North American Congress of Clinical Toxicology.  Chicago, IL. October, 2018. Poster
  • Ngo A, Rege S, Ait-Daoud N, Holstege C.  Trends and Determinants of Student Hazardous Drinking – A comparative analysis using multiple datasets in a U.S. Public University.  European Society for Emergency Medicine 2018 Congress.  Glasgow, Scotland.  September 8-12, 2018. Presentation
  • Ngo DA, Rege S, Ait-Daoud N, Holstege CP. Trends and Risk Markers of Emergency Department Visits with Alcohol Intoxication Among Students in a Public University—a Longitudinal Data Linkage Study.  Journal of Medical Toxicology 2018;14:17. Presented at the ACMT Annual Scientific Meeting - Washington, DC.  April, 2018. Poster
  • Ngo DA, Rege S, Ait-Daoud N, Holstege CP. Drinking Among High-Risk Students Receiving the Brief Alcohol Screening and Intervention in a Public University in the USA.  Journal of Medical Toxicology 2018;14:17. Presented at the ACMT Annual Scientific Meeting - Washington, DC.  April, 2018. Poster
  • Holstege CP, Ngo DA, Rege S, Ait-Daoud N. Trends and risk markers of emergency department visits with alcohol intoxication among students in a public university – A longitudinal data linkage study. European Psychiatry (supplement) 2018;49. 26th European Congress of Psychiatry (European Psychiatric Association - EPA). Nice, France. March 2018. Poster
  • Holstege CP, Ngo DA, Rege S, Ait-Daoud N.  Drinking among high risk students receiving the brief alcohol screening and intervention in a U.S. public university.  European Psychiatry (supplement) 2018;49. 26th European Congress of Psychiatry (European Psychiatric Association - EPA). Nice, France.  March 2018. Poster
  • Ngo DA, Ait-Daoud, N Holstege CP, Rege S. Ding C, Miley L, Rege S. Validity of code-based recording of alcohol intoxication among college students presenting to a university hospital emergency department. Ann Emerg Med 2017;70(4):S69-70. American College of Emergency Physicians Research Forum. Washington, DC. October, 2017. Presentation
  • Ngo DA, Holstege CP, Ait-Daoud N, Rege S, Gallion L, Ding C. Trends in alcohol intoxication among students presenting to a university hospital emergency department using code-based records.  North American Congress of Clinical Toxicology.  Clin Tox 2017;55(7):791.  Vancouver, Canada.  October, 2017. Poster
  • Nobles AL*, Ngo DA, Curtis B, Holstege CP. Health Insurance Literacy Among College Students. American College Health Association Annual Meeting.  San Antonio, TX. 2017. Poster
  • Ngo DA*, Tolley W, Holstege CP. Trends In and Risk Markers of Sexually Transmitted Infections in University Students in the United States – Findings from the College Health Surveillance Network.  American College Health Association Annual Meeting. San Antonio, TX.  2017. Poster
  • Torbey S*, Robinson DM, Vakkalanka P, Holstege CP, Thomson JA. A Silent Epidemic: Suicidality in the College Student Population. American Academy of Children and Adolescent Psychiatry 63rd Annual Meeting. New York City, New York, 2016. Poster
  • Blevins D*, Vakkalanka P, Robinson D, Khanna, SK, Ait-Daoud Tiouririne N, Holstege CP. Impact of Substance Abuse Discharge Recommendation Compliance on ED Readmission Rate in a College Population. American Psychiatric Association Annual Meeting. Atlanta, Georgia, 2016. Poster
  • Torbey S*, Robinson DM, Vakkalanka P, Holstege CP, Thomson JA. Suicide crisis on campus: Suicide attempts and ideation in the collegiate population evaluated in the emergency department. American Psychiatric Association Annual Meeting. Atlanta, Georgia, 2016.
  • Vakkalanka P., Ruzek N, Holstege CP. Student Health Center Response to a Crisis on Campus. American College Health Association Annual Meeting.  San Francisco, CA. 2016. Poster
  • Vakkalanka JP, Ait-Daoud Tiouririne N, Blevins D, Robinson D, Khanna S, Holstege CP*.  The Epidemiology of Alcohol and Substance-Related Emergency Department Admissions within a University Population. Clinical Toxicology (publication pending). NACCT. San Francisco, CA. 2015. Poster
  • Vakkalanka JP, King J*, Holstege CP. Intentional exposures on school property reported to US Poison Centers. Clinical Toxicology 2015;53(4):242.  EAPCCT. St. Julian's, Malta. 2015.
  • Blevins D, Khanna S, Vakkalanka P, Holstege CP, Ait-Daoud, N.  Prevalence and Impact of Substance and Alcohol Misuse on College Students Presenting to the Emergency Department and Evaluation of Practical Referrals. 168th American Psychiatric Association Annual Meeting. Toronto, Canada. 2015. Poster